منابع مشابه
Genetic recombination in Streptomyces griseus.
Low-frequency (10(-6)) genetic recombination was observed in a cephamycin-producing strain of Streptomyces griseus. The recombinants were predominantly heteroclones. Heteroclone analysis was performed involving four heteroclones of one cross. In 100 mutants correlation was found between the type of auxotrophy and the level of antibiotic activity. A cross of this strain with a streptomycin-produ...
متن کاملOxidation of Meloxicam by Streptomyces griseus
The aim of the present investigation was to biotransform the anti-inflammatory compound meloxicam by enzymes present in whole cells of five actinomycete cultures to produce novel bioactive derivatives. Among the actinomycetes screened, Streptomyces griseus NCIM 2622 was found to possess the enzyme system(s) that oxidize meloxicam into two metabolites whereas that present in S. griseus NCIM 2623...
متن کاملLow Frequency Motion in ProteinsComparison of Normal Mode and Molecular Dynamicsof Streptomyces Griseus Protease A
Pnina Dauber-Osguthorpe,∗ David J. Osguthorpe,† Peter S. Stern,‡ and John Moult§ ∗Department of Biology and Biochemistry and †School of Chemistry, University of Bath, Bath, Avon, BA2 7AY, England; ‡Chemical Physics Department, Weizmann Institute of Science, Rehovot, Israel; and §Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, R...
متن کاملSporulation of Streptomyces griseus in submerged culture.
A wild-type strain of Streptomyces griseus forms spores both on solid media (aerial spores) and in liquid culture (submerged spores). Both spore types are highly resistant to sonication, but only aerial spores are resistant to lysozyme digestion. Electron micrographs suggest that lysozyme sensitivity may result from the thinner walls of the submerged spores. Studies of the life cycle indicate t...
متن کاملChromosomal arm replacement in Streptomyces griseus.
UV irradiation of Streptomyces griseus 2247 yielded a new chromosomal deletion mutant, MM9. Restriction and sequencing analysis revealed that homologous recombination between two similar lipoprotein-like open reading frames, which are located 450 and 250 kb from the left and right ends, respectively, caused chromosomal arm replacement. As a result, new 450-kb terminal inverted repeats (TIRs) we...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.13.7594